A New Ketone Synthesis

A New Synthesis

We are on the eve of a revolution in health policy that will forever change our way of thinking about health and healthcare. A few years from now, our vision of the organization and the administration of healthcare services will be transformed.   This is not a revolution born out of crisis, albeit the financial pressure on public and private funders of healthcare is clearly at play. It has not ...

A New Synthesis in Search of Synthesizing Agents; Comment on “A New Synthesis”

In a recent editorial in this journal Pierre-Gerlier Forest foretells a coming revolution in health policy based on the synthesis of four conceptual innovations and one technological breakthrough. As much as I agree with the intellectual story told in this editorial I present a more skeptical view of the effect of paradigm shifts on healthcare systems on the ground. I argue that ideas triumph w...

Aromatic polymers obtained by precipitation polycondensation: 4". Synthesis of poly(ether ketone ketone)s

High molecular weight aromatic poly(ether ketone ketone)s were synthesized by the Friedel-Crafts polyacylation condensation of isoand terephthaloyl chlorides with diphenyl ether, 1,4and 1,3-bis(4phenoxybenzoyl)benzenes. Depending on the monomers used for polycondensation, polyketones of regular structure with different iso-/tereisomer repeating unit ratio (100/0, 50/50, 0/100) in the main chain...

Ketone-imide versus ketone-oxime reductive cross-coupling promoted by samarium diiodide: new mechanistic insight gained from a failed aminocyclopentitol synthesis.

[reaction: see text] The intramolecular 1,6-ketone/imide reductive coupling promoted by samarium diiodide competes favorably with an alternative 1,5-ketone/oxime ether coupling in a keto-oxime substrate derived from D-glucosamine N-protected with a phthalimido group. This pinacol coupling reaction affords new homochiral alpha-hydroxylactam scaffolds that could be useful in diversity-oriented sy...

Synthesis and Characterization of New Phosphine oxide and Ketone Containing Poly(Arylene Sulfide Sulfone)s